By a News Reporter-Staff News Editor at Diabetes Week Researchers detail new data in Diabetes. According to news reporting from Konya, Turkey, by NewsRx journalists, research stated, "An increased prevalence of masked hypertension (MHT) has been demonstrated among patients with diabetes mellitus (DM). MHT appears to cause cardiovascular (CV) complications similar to clinically overt hypertension."
The news correspondents obtained a quote from the research from Research Hospital, "Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased CV risk in both the general population and among patients with DM. The aim of this study was to evaluate the relationship between MHT and ADMA in diabetic patients. This study included DM patients (n = 131) with normal office blood pressure (<140/90 mmHg). None of the participants were using antihypertensive medications. All participants utilized an ambulatory blood pressure monitor (ABPM) for 24 h. Serum ADMA and arginine levels were measured using the fluorescence detector high performance liquid chromatography method. The prevalence of MHT was 24.4% among the study subjects. ADMA levels were increased in the MHT group when compared with normotensive diabetics (6.2 +/- 2.2 vs 4.2 +/- 1.7 mu mol/L p = 0.001, respectively). Furthermore, arginine/ADMA ratio was lower in the MHT group than among the normotensive group (29.9 +/- 12.1 vs 46.0 +/- 19.0 p = 0.001). In the multivariate logistic regression model, ADMA, BMI and HDL levels were found to be independent predictors of MHT Odds ratio: 1.63 (1.28-2.06), 1.19 (1.05-1.35), and 0.95 (0.90-0.99), respectively. The cut-off value of the ADMA was 4.34 mu mol/L with a sensitivity, specificity, positive predictive value, and negative predictive value of 84.4%, 59.6%, of 40.3%, and 92.2%, respectively (AUC - 0.78)."
According to the news reporters, the research concluded: "Serum ADMA may play a role in both the pathophysiology and screening of MHT in DM subjects."
For more information on this research see: The value of serum asymmetric dimethylarginine levels for the determination of masked hypertension in patients with diabetes mellitus. Atherosclerosis, 2013;228(2):432-437. Atherosclerosis can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Atherosclerosis - www.elsevier.com/wps/product/cws-home/522790)
Our news journalists report that additional information may be obtained by contacting A. Taner, Konya Training & Res Hosp, Dept. of Biochem, Konya, Turkey (see also Diabetes).
Keywords for this news article include: Konya, Turkey, Eurasia, Hypertension, Endocrinology, Type 2 Diabetes, Metabolic Diseases, Cardiovascular Diseases, Endocrine System Diseases, Glucose Metabolism Disorders, Non-Insulin Dependent Diabetes Mellitus
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