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 The leading web portal for pharmacy resources, news, education and careers May 21, 2018
Pharmacy Choice - Pharmaceutical News - Data on Immunoglobulins Described by Researchers at Aretaieion Hospital [Expression of extracellular domains of muscle specific kinase (MuSK) and use... - May 21, 2018

Pharmacy News Article

 1/5/15 - Data on Immunoglobulins Described by Researchers at Aretaieion Hospital [Expression of extracellular domains of muscle specific kinase (MuSK) and use...

Data on Immunoglobulins Described by Researchers at Aretaieion Hospital [Expression of extracellular domains of muscle specific kinase (MuSK) and use as immunoadsorbents for the development of an antigen-specific therapy]

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week Data detailed on Immunology have been presented. According to news reporting originating in Athens, Greece, by NewsRx journalists, research stated, "Antibodies against MuSK seem to be the pathogenic factor in approximately 5-8% of myasthenia gravis (MG) patients."

The news reporters obtained a quote from the research from Aretaieion Hospital, "We aim to develop an antigen-specific therapy in which only MuSK antibodies will be removed from patients' plasma using MuSK extracellular domain (MuSK-ECD) as immunoadsorbent We showed that two different immunoadsorbents, very efficiently and selectively depleted the MuSK antibodies from all tested sera, were stable during the procedure and were reusable. Furthermore, animal experiments showed that the treatment has no toxic effects to the animals."

According to the news reporters, the research concluded: "We conclude that the MuSK-ECD-mediated immunoadsorption can be used as an efficient antigen-specific therapy for MuSK-MG."

For more information on this research see: Expression of extracellular domains of muscle specific kinase (MuSK) and use as immunoadsorbents for the development of an antigen-specific therapy. Journal of Neuroimmunology, 2014;276(1-2):150-158. Journal of Neuroimmunology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Neuroimmunology - www.elsevier.com/wps/product/cws-home/506023)

Our news correspondents report that additional information may be obtained by contacting L. Skriapa, Aretaieion Hosp, Dept. of Nephrolagy, Athens, Greece. Additional authors for this research include P. Zisimopoulou, N. Trakas, E. Grapsa and S.J. Tzartos (see also Immunology).

Keywords for this news article include: Antibodies, Athens, Greece, Europe, Kinase, Therapy, Immunology, Blood Proteins, Immunoglobulins, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2015, NewsRx LLC



(c) 2015 NewsRx LLC

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