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 The leading web portal for pharmacy resources, news, education and careers October 20, 2018
Pharmacy Choice - Pharmaceutical News - New Findings on Thrombosis from Department of Surgery Summarized (Hemodialysis Catheter Design and Catheter Performance: A Randomized Controlled... - October 20, 2018

Pharmacy News Article

 1/5/15 - New Findings on Thrombosis from Department of Surgery Summarized (Hemodialysis Catheter Design and Catheter Performance: A Randomized Controlled...

New Findings on Thrombosis from Department of Surgery Summarized (Hemodialysis Catheter Design and Catheter Performance: A Randomized Controlled Trial)

By a News Reporter-Staff News Editor at Clinical Trials Week New research on Cardiovascular Diseases and Conditions is the subject of a report. According to news reporting originating in Brugge, Belgium, by NewsRx journalists, research stated, "A complication of long-term use of tunneled cuffed catheters for hemodialysis is the high rate of infection and thrombus-related dysfunction. Specific mechanical features of tunneled cuffed catheters may improve hemodynamic performance and decrease thrombosis and infection rates."

The news reporters obtained a quote from the research from the Department of Surgery, "However, there currently is no proven advantage of one design over another. Single-center randomized clinical trial. 302 hemodialysis patients who required a tunneled cuffed catheter as temporary or definite vascular access. Palindrome Symmetric Tip Dialysis Catheter or HemoStar Long-Term Hemodialysis Catheter. The primary end point was primary assisted patency. Secondary end points were incidence of catheter-related bloodstream infections (CRBSIs), thrombosis, and 2 indicators of rheologic function: mean effective blood flow rate and urokinase use. Mean primary assisted patency was 135.9 days for Palindrome and 136.5 days for HemoStar (P = 0.8). Definite CRBSI occurred in 0.24 and 0.10/1,000 catheter-days for Palindrome and HemoStar, respectively (P = 0.3). Removal rates for thrombosis that could not be resolved with thrombolysis were 0.53 and 0.43/1,000 catheter-days for Palindrome and HemoStar, respectively (P = 0.7). Urokinase use was lower for Palindrome than for HemoStar, as evidenced by a lower number of urokinase infusions/1,000 catheter-days (17 and 35; P< 0.001) and higher number of catheters that never required thrombolysis (58% and 45%; P = 0.03). Mean effective blood flow rate was higher for Palindrome than for HemoStar (333 and 304 mL/min; P< 0.001). Limitations: Single-center nonblinded trial. Primary assisted patency and incidence of infection and thrombosis were similar for both catheter types. The Palindrome catheter required less thrombolysis and achieved higher blood flow rates than the HemoStar catheter."

According to the news reporters, the research concluded: "These findings suggest that mechanical catheter design may improve catheter rheology, but does not affect risks for thrombosis and infection and hence catheter survival."

For more information on this research see: Hemodialysis Catheter Design and Catheter Performance: A Randomized Controlled Trial. American Journal of Kidney Diseases, 2014;64(6):902-908. American Journal of Kidney Diseases can be contacted at: W B Saunders Co-Elsevier Inc, 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, PA 19103-2899, USA. (Elsevier - www.elsevier.com; American Journal of Kidney Diseases - www.elsevier.com/wps/product/cws-home/623276)

Our news correspondents report that additional information may be obtained by contacting H. Van der Meersch, AZ Sint Jan Brugge, Dept. of Surg, B-8000 Brugge, Belgium. Additional authors for this research include D. De Bacquer, S.J. Vandecasteele, B. Van den Bergh, P. Vermeiren, J. De Letter and A.S. De Vriese (see also Cardiovascular Diseases and Conditions).

Keywords for this news article include: Brugge, Europe, Belgium, Hematology, Hemodialysis, Thrombolysis, Renal Dialysis, Embolism and Thrombosis, Clinical Trials and Studies, Cardiovascular Diseases and Conditions

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2015, NewsRx LLC



(c) 2015 NewsRx LLC

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