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 The leading web portal for pharmacy resources, news, education and careers March 17, 2018
Pharmacy Choice - Pharmaceutical News - Tokai Pharmaceuticals Posts Preclinical Results from the University of Maryland Showing Galeterone and Analogs Inhibit Pancreatic Cancer Cell Growth [Manufacturing Close - Up] - March 17, 2018

Pharmacy News Article

 4/23/15 - Tokai Pharmaceuticals Posts Preclinical Results from the University of Maryland Showing Galeterone and Analogs Inhibit Pancreatic Cancer Cell Growth [Manufacturing Close - Up]

Tokai Pharmaceuticals reported that scientists in the laboratory of Vincent Njar, PhD, at the University of Maryland School of Medicine presented preclinical data showing that galeterone and novel analogs of galeterone inhibited growth, survival and migration of human pancreatic ductal adenocarcinoma (PDAC) cells.

In a release, the Company noted that these data were presented in a poster presentation titled, "Galeterone and Its Novel Analogs Induce Profound Anti-Cancer Activities in Human Pancreatic Cancer Cell Lines," abstract number 1764, at the 2015 American Association for Cancer Research (AACR) in Philadelphia, Pennsylvania.

"We are excited to see the activity of galeterone and its novel analogs in pancreatic cancer cells," stated Jodie Morrison, President and Chief Executive Officer of Tokai Pharmaceuticals. "Based on these data we believe galeterone and its novel analogs may have activity in this tumor type where there is a significant need for new therapies. These preclinical results also support the potential of galeterone beyond its lead indication in prostate cancer and further demonstrate the potential of the ARDA platform."

Tokai Pharmaceuticals said that Galeterone and its novel analogs were found to reduce PDAC cell proliferation, cell viability, and colony formation ability using both gemcitabine-naive and gemcitabine-resistant cell lines and also acted synergistically with gemcitabine to further enhance anti-proliferative effects. Additional in vitro assays demonstrated that galeterone and its analogs reduced tumor cell migration, invasion and reduced MMP9 secretion. At a molecular level, galeterone modulated oncotargets and translational machinery, including the Mink1/2-eIF4E axis.

Tokai Pharmaceuticals is a biopharmaceutical company focused on developing novel therapies for prostate cancer and other hormonally- driven diseases.

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