New Drug Delivery Systems Findings Reported from University of Bath (Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin)
By a News Reporter-Staff News Editor at Biotech Week Data detailed on Drugs and Therapies have been presented. According to news reporting from Avon, United Kingdom, by NewsRx journalists, research stated, "Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation."
The news correspondents obtained a quote from the research from the University of Bath, "Their application convenience and cosmetic attributes, superior to conventional semi-solids, may offer improved patient compliance. This study represents the first phase of an investigation into the use of FFSs for prolonged dermal drug delivery. FFS formulations were distinguished based on their ability to sustain the release of betamethasone 17-valerate (BMV) in vitro over 72 h. The effect of film-forming polymer (hydrophilic: hydroxypropyl cellulose (Klucel ? LF); hydrophobic: polymethacrylate copolymers (Eudragit NE and Eudragit RS), and polyacrylate copolymer (Dermacryl 79) was first determined, and then the impact of incorporation of plasticisers (triethyl citrate, tributyl citrate, and dibutyl sebacate) was examined. The Klucel film released a significantly higher amount of BMV than the hydrophobic FFS, 42 versus 4 mu g/cm(2), respectively. The release was increased when a plasticiser was incorporated, and with higher enhancement ratios achieved with the more lipophilic plasticisers."
According to the news reporters, the research concluded: "The results show that FFSs can sustain drug release (hence representing useful systems for prolonged dermal therapy) and emphasise the importance of the formulation on drug delivery, with the type of polymer being of greatest significance."
For more information on this research see: Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin. European Journal of Pharmaceutics and Biopharmaceutics, 2015;91():9-15. European Journal of Pharmaceutics and Biopharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.elsevier.com/wps/product/cws-home/600120)
Our news journalists report that additional information may be obtained by contacting K. Frederiksen, University of Bath, Dept. of Pharm & Pharmacol, Bath, Avon, United Kingdom. Additional authors for this research include R.H. Guy and K. Petersson (see also Drugs and Therapies).
Keywords for this news article include: Avon, Europe, United Kingdom, Drugs and Therapies, Drug Delivery Systems
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