Recent Studies from University Hospital Schleswig-Holstein Add New Data to Colon Cancer (Identifying patients with an unfavorable prognosis in early stages of colorectal carcinoma)
By a News Reporter-Staff News Editor at Cancer Weekly Data detailed on Oncology - Colon Cancer have been presented. According to news reporting out of Kiel, Germany, by NewsRx editors, research stated, "In recent years, the concept of liquid biopsy diagnostics in detection and progress monitoring of malignant diseases gained significant awareness. We here report on a semi-quantitative real-time cytokeratin 20 RT-PCR-based assay, for detecting circulating tumor cells within a fraction of peripheral blood mononuclear cells in colorectal cancer patients."
Our news journalists obtained a quote from the research from University Hospital Schleswig-Holstein, "In total, 381 patients were included. Prior to surgical tumor resection, a peripheral blood sample was drawn. Mononuclear cells were isolated by Ficoll centrifugation and a cytokeratin 20 qRT-PCR assay was performed. Quantitative PCR data was assessed regarding histopathological characteristics and patients? clinical outcome. A cut-off value was determined at greater than or equal to 2.77 [EU]. Stratifying patients by this cut-off, it represents a statistically highly significant prognostic marker for both the overall and disease-free survival in the entire cohort UICC I-IV (both p<0.001) and in early tumor stages UICC I+II (overall survival p=0.003 and disease-free survival p=0.005). In multivariate analysis, the cut-off value stands for an independent predictor of significantly worse overall and disease-free survival (p=0.035 and p=0.047, respectively)."
According to the news editors, the research concluded: "We successfully established a highly sensitive real-time qRT-PCR assay by which we are able to identify colorectal cancer patients at risk for an unfavorable prognosis in UICC I and II stages."
For more information on this research see: Identifying patients with an unfavorable prognosis in early stages of colorectal carcinoma. Oncotarget, 2018;9(44):27423-27434 (see also Oncology - Colon Cancer).
Our news journalists report that additional information may be obtained by contacting A. Hendricks, Dept. of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. Additional authors for this research include G.L. Eggebrecht, A. Bernsmeier, R. Geisen, K. Dall, A. Trauzold, T. Becker, H. Kalthoff, C. Schafmayer, C. Roder and S. Hinz.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.18632/oncotarget.25384. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Kiel, Europe, Germany, Oncology, Carcinomas, Colon Cancer, Epidemiology, Gastroenterology, Survival Analysis, Colorectal Research, Health and Medicine, Statistics as Topic, Disease Free Survival, Environment and Public Health.
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