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 The leading web portal for pharmacy resources, news, education and careers January 20, 2019
Pharmacy Choice - Pharmaceutical News - New Findings on Liver Cancer from First Affiliated Hospital Summarized (Metavir and FIB-4 scores are associated with patient prognosis after curative... - January 20, 2019

Pharmacy News Article

 2/28/17 - New Findings on Liver Cancer from First Affiliated Hospital Summarized (Metavir and FIB-4 scores are associated with patient prognosis after curative...

New Findings on Liver Cancer from First Affiliated Hospital Summarized (Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort ...)

By a News Reporter-Staff News Editor at China Weekly News Research findings on Oncology - Liver Cancer are discussed in a new report. According to news reporting originating in Chongqing, People's Republic of China, by VerticalNews journalists, research stated, "Although Metavir and Fibrosis-4 (FIB-4) scores are typically used to assess the severity of liver fibrosis, the relationship between these scores and patient outcome in hepatocellular carcinoma (HCC) is unclear. The aim of this study was to evaluate the prognostic value of the severity of hepatic fibrosis in HBV-related HCC patients after curative resection."

The news reporters obtained a quote from the research from First Affiliated Hospital, "We examined the prognostic roles of the Metavir and preoperative FIB-4 scores in 432 HBV-HCC patients who underwent curative resection at two different medical centers located in western (Chongqing) and eastern (Shanghai) China. In the testing set (n=108), the Metavir, FIB-4, and combined Metavir/FIB-4 scores were predictive of overall survival (OS) and recurrence-free survival (RFS). Additionally, they were associated with several clinicopathologic variables. In the validation set (n=324), the Metavir, FIB-4, and combined Metavir/FIB-4 scores were associated with poor prognosis in HCC patients after curative resection. Importantly, in the negative alpha-fetoprotein subgroup ( less than or equal to 20 ng/mL), the FIB-4 index (I vs. II) could discriminate between patient outcomes (high or low OS and RFS)."

According to the news reporters, the research concluded: "Thus Metavir, preoperative FIB-4, and combined Metavir/FIB-4 scores are prognostic markers in HBV-HCC patients after curative hepatectomy."

For more information on this research see: Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in China. Oncotarget, 2017;8(1):1774-1787.

Our news correspondents report that additional information may be obtained by contacting R. Liao, Dept. of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China. Additional authors for this research include Y.P. Fu, T. Wang, Z.G. Deng, D.W. Li, J. Fan, J. Zhou, G.S. Feng, S.J. Qiu and C.Y Du.

Keywords for this news article include: Surgery, Oncology, Virology, Chongqing, Carcinomas, Hepatology, DNA Viruses, Hepatectomy, Liver Cancer, Hepadnaviridae, Gastroenterology, Hepatitis B Virus, Orthohepadnavirus, People's Republic of China, Liver Diseases and Conditions, Infectious Diseases and Conditions, Digestive System Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC



(c) 2017 NewsRx LLC

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