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 The leading web portal for pharmacy resources, news, education and careers November 21, 2017
Pharmacy Choice - Pharmaceutical News - Findings on Clinical Trials and Studies Discussed by Investigators at University of North Carolina (A Randomized Clinical Trial Comparing 2 Ibuprofen... - November 21, 2017

Pharmacy News Article

 6/5/17 - Findings on Clinical Trials and Studies Discussed by Investigators at University of North Carolina (A Randomized Clinical Trial Comparing 2 Ibuprofen...

Findings on Clinical Trials and Studies Discussed by Investigators at University of North Carolina (A Randomized Clinical Trial Comparing 2 Ibuprofen Formulations in Patients with Acute Odontogenic Pain)

By a News Reporter-Staff News Editor at Clinical Trials Week Fresh data on Clinical Research - Clinical Trials and Studies are presented in a new report. According to news reporting from Chapel Hill, North Carolina, by NewsRx journalists, research stated, "Ibuprofen sodium dihydrate, a new formulation of ibuprofen, was introduced with the claim of faster onset of analgesia. Most of the data on this new ibuprofen formulation are drawn from studies using the oral surgery model."

Financial support for this research came from American Association of Endodontists Foundation (see also Clinical Research - Clinical Trials and Studies).

The news correspondents obtained a quote from the research from the University of North Carolina, "Because this model differs significantly from the endodontic pain model, we conducted a study comparing ibuprofen sodium dihydrate with conventional ibuprofen acid in endodontic pain patients. This randomized, double-masked study recruited subjects experiencing moderate to severe pain from a tooth diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis (n = 41). Subjects were randomized to receive 400 mg ibuprofen acid (Advil; Pfizer, Madison, NJ) or an equivalent dose of 512 mg ibuprofen sodium dihydrate (Advil Sodium, Pfizer). The outcome measures were time to onset of 50% pain relief recorded using a stopwatch, reduction in spontaneous pain experienced on a 100-mm visual analog scale, and change in mechanical allodynia measured using a bite force transducer. The last 2 measures were obtained before and 60 minutes after administration of the drug. The median time to onset of 50% pain relief after administration of ibuprofen sodium dihydrate was significantly faster compared with ibuprofen acid (26.5 vs 44 minutes, P = .08). Ibuprofen sodium dihydrate provided a greater reduction in spontaneous pain (50.8% vs 33.3%, P< .05) and mechanical allodynia (15% vs 9%, P> .05)."

According to the news reporters, the research concluded: "In endodontic pain patients, a single dose of ibuprofen sodium dihydrate provides faster onset of pain relief and a greater reduction in spontaneous and evoked pain compared with ibuprofen acid."

For more information on this research see: A Randomized Clinical Trial Comparing 2 Ibuprofen Formulations in Patients with Acute Odontogenic Pain. Journal of Endodontics, 2017;43(5):674-678. Journal of Endodontics can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Journal of Endodontics - www.journals.elsevier.com/journal-of-endodontics/)

Our news journalists report that additional information may be obtained by contacting A.A. Khan, Univ North Carolina Chapel Hill, Dept. of Endodont, Chapel Hill, NC 27599, United States. Additional authors for this research include D. Wu and T. Taggar.

Keywords for this news article include: Chapel Hill, North Carolina, United States, North and Central America, Clinical Trials and Studies, Pharmaceutical Companies, Drugs and Therapies, Ibuprofen Therapy, Phenylpropionates, Clinical Research, Pain Management, Pharmaceuticals, Endodontics, Pfizer, University of North Carolina.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC



(c) 2017 NewsRx LLC

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