New Liver Cancer Data Have Been Reported by Researchers at General Hospital of PLA (Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis)
By a News Reporter-Staff News Editor at Cancer Weekly Fresh data on Oncology - Liver Cancer are presented in a new report. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Thymidylate synthase (TYMS), a key rate-limiting enzyme in the folate metabolism, plays essential roles in the development of several malignancies including hepatocellular carcinoma (HCC). Nonetheless, the association of the single nucleotide polymorphisms (SNPs) in TYMS gene with the prognosis of Chinese HCC patients remains unknown."
The news correspondents obtained a quote from the research from the General Hospital of PLA, "A total of 492 HCC patients who underwent surgery treatment were included in this study. Five functional SNPs (rs2847153, rs2853533, rs502396, rs523230, and rs9967368) in TYMS gene were genotyped using the iPLEX genotyping system. Multivariate Cox proportional hazards regression model and Kaplan-Meier curve were used to analyze the association of SNPs with survival and recurrence of HCC patients. Two SNPs (rs523230 and rs9967368) in TYMS gene were significantly associated with the overall survival of HCC patients. Patients carrying homozygous variant genotype (VV) of rs523230 had significantly decreased risk of death (hazard ratio[HR], 0.68; 95% confidence interval [CI], 0.46-1.00; P = 0.048) when compared with those carrying homozygous wild-type (WW) or heterozygous (WV) genotypes, while patients carrying WV + VV genotype of rs9967368 had significantly increased risk of death (HR, 1.46; 95% CI, 1.05-2.04; P = 0.026) when compared with those carrying WW genotypes. Cumulative effect analysis showed a significant dose-dependent effect of unfavorable SNPs on OS."
According to the news reporters, the research concluded: "Our study for the first time demonstrates the association of SNPs in TYMS gene and clinical outcome of HCC, suggesting that rs523230 and rs9967368 in TYMS gene might be used to predict clinical outcome of Chinese HCC patients."
For more information on this research see: Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis. Clinics and Research in Hepatology and Gastroenterology, 2017;41(3):319-326. Clinics and Research in Hepatology and Gastroenterology can be contacted at: Elsevier Masson, Via Paleocapa 7, 20121 Milano, Italy. (Elsevier - www.elsevier.com; Clinics and Research in Hepatology and Gastroenterology - www.journals.elsevier.com/clinics-and-research-in-hepatology-and-gastroenterology/)
Our news journalists report that additional information may be obtained by contacting G. Dong, Gen Hosp PLA, Dept. of Gen Surg, Beijing 100853, People's Republic of China. Additional authors for this research include X. Sun, X. Du, F. Zhou, F. Yang, J. Xing, X. Wang and X. Guo (see also Oncology - Liver Cancer).
Keywords for this news article include: Beijing, People's Republic of China, Asia, Synthase, Risk and Prevention, Genetics, Enzymes and Coenzymes, Thymidylate Synthase, Methyltransferases, Liver Cancer, Carcinomas, Oncology, General Hospital of PLA.
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